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Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy

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Abstract

Aim

The aim of this study is to assess the changes in coagulation, thrombosis, anticoagulation, and fibrinolysis during early pregnancy.

Methods

One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured.

Results

Fg, F1 + 2, thrombin–antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased.

Conclusion

Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.

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Acknowledgments

This research was supported by Grants of National Natural Science Foundation of China (81000259), Guangdong Natural Science Foundation (NO.10451008901004246) and Research Fund for the Doctoral Program of Higher Education of China (NO. 20090171120075).

Conflict of interest

The authors declare that we have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Yanjiang Road 107, Guangdong, Guangzhou, China

    H. Chen, L. Meng, M. Liu, J. Tan & J. Zhang

  2. Department of Emergency, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    L. Zhou

  3. Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Road II 58, Guangdong, Guangzhou, China

    L. Gao

Authors
  1. H. Chen
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  2. L. Zhou
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  3. L. Meng
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  4. M. Liu
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  5. J. Tan
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  6. L. Gao
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  7. J. Zhang
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Corresponding author

Correspondence to J. Zhang.

Additional information

H. Chen and L. Zhou contributed equally to this work.

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Chen, H., Zhou, L., Meng, L. et al. Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy. Ir J Med Sci 180, 813–817 (2011). https://doi.org/10.1007/s11845-011-0737-x

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  • DOI: https://doi.org/10.1007/s11845-011-0737-x

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