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Journal = Pharmaceuticals
Volume = 3
Issue = 3
Page = 679

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Article
2-Deoxystreptamine Conjugates by Truncation–Derivatization of Neomycin
by M. Waqar Aslam, Leandro C. Tabares, Alessio Andreoni, Gerard W. Canters, Floris P.J.T. Rutjes and Floris L. Van Delft
Pharmaceuticals 2010, 3(3), 679-701; https://doi.org/10.3390/ph3030679 - 15 Mar 2010
Cited by 3 | Viewed by 12572
Abstract
A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conjugates were evaluated for antibacterial activity with a unique hemocyanin-based biosensor. Based on the outcome of these [...] Read more.
A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conjugates were evaluated for antibacterial activity with a unique hemocyanin-based biosensor. Based on the outcome of these results, a second-generation set of monomeric conjugates was prepared and found to display significant antibacterial activity, in particular with respect to kanamycin-resistant E. coli. Full article
(This article belongs to the Special Issue Antibiotics)
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