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Pediatric Reports
Volume 3
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10.4081/pr.2011.e28
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Brief Report

B-Lymphocyte Reconstitution after Repeated Rituximab Treatment in a Child with Steroid-Dependent Autoimmune Hemolytic Anemia

by
Annelieke A.A. van der Linde
1,
Ellen J.H. Schatorjé
1,
Annemieke M. van der Weij
1,
Eugenie F.A. Gemen
2 and
Esther de Vries
1,*
1
Department of Pediatrics
2
Laboratory of Hematology and Clinical Chemistry, Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2011, 3(4), e28; https://doi.org/10.4081/pr.2011.e28
Submission received: 12 May 2011 / Revised: 18 September 2011 / Accepted: 26 October 2011 / Published: 13 December 2011

Abstract

We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.
Keywords: autoimmune hemolytic anemia; rituximab; child; immune reconstitution; B-lymphocytes autoimmune hemolytic anemia; rituximab; child; immune reconstitution; B-lymphocytes

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MDPI and ACS Style

van der Linde, A.A.A.; Schatorjé, E.J.H.; van der Weij, A.M.; Gemen, E.F.A.; de Vries, E. B-Lymphocyte Reconstitution after Repeated Rituximab Treatment in a Child with Steroid-Dependent Autoimmune Hemolytic Anemia. Pediatr. Rep. 2011, 3, e28. https://doi.org/10.4081/pr.2011.e28

AMA Style

van der Linde AAA, Schatorjé EJH, van der Weij AM, Gemen EFA, de Vries E. B-Lymphocyte Reconstitution after Repeated Rituximab Treatment in a Child with Steroid-Dependent Autoimmune Hemolytic Anemia. Pediatric Reports. 2011; 3(4):e28. https://doi.org/10.4081/pr.2011.e28

Chicago/Turabian Style

van der Linde, Annelieke A.A., Ellen J.H. Schatorjé, Annemieke M. van der Weij, Eugenie F.A. Gemen, and Esther de Vries. 2011. "B-Lymphocyte Reconstitution after Repeated Rituximab Treatment in a Child with Steroid-Dependent Autoimmune Hemolytic Anemia" Pediatric Reports 3, no. 4: e28. https://doi.org/10.4081/pr.2011.e28

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