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Keywords = B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia.
Authors = linde
Journal = Pediatric Reports

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Brief Report
B-Lymphocyte Reconstitution after Repeated Rituximab Treatment in a Child with Steroid-Dependent Autoimmune Hemolytic Anemia
by Annelieke A.A. van der Linde, Ellen J.H. Schatorjé, Annemieke M. van der Weij, Eugenie F.A. Gemen and Esther de Vries
Pediatr. Rep. 2011, 3(4), e28; https://doi.org/10.4081/pr.2011.e28 - 13 Dec 2011
Cited by 1 | Viewed by 2
Abstract
We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower [...] Read more.
We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values. Full article
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